Some Observations Regarding the Toxicity of Thiamin Chloride and Nicotinic Acid
نویسنده
چکیده
While working on the heart of Rana tigrina by the perfusion method recommended by Burridge (1935), I started with a fairly concentrated solution of pure synthetic thiamin chloride in concentration of one part in 1,000 of Ringer and watched the results. No sooner the drug was perfused than the heart, which had been beating normally so far, was suddenly arrested in diastole and remained as such throughout the jperiod of drug perfusion. It, however, started beating strongly again when the Ringer was reperfused (see figure 1, plate
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